Peptide drugs for photopharmacology: how much of a safety advantage can be gained by photocontrol? Oleg Babii, Sergii Afonin, Tim Schober, Liudmyla V Garmanchuk, Liudmyla I Ostapchenko, Volodymyr Yurchenko, Sergey Zozulya, Oleksandr Tarasov, Iryna Pishel, Anne S Ulrich & Igor V Komarov. Future Drug. Discov. 2020, (Epub ahead of print) DOI 10.4155/fdd-2019-0033
Light-controllable dithienylethene-modified cyclic peptides: photoswitching the in vivo toxicity in zebrafish embryos. Sergii Afonin, Oleg Babii, Aline Reuter, Volker Middel, Masanari Takamiya, Uwe Strähle, Igor V Komarov, Anne S Ulrich Beilstein J. Org. Chem., 2020, 16, pp 39–49 DOI: 10.3762/bjoc.16.6
Demonstration of the photoswitching technology on compounds developed under the Project to children. It is fun indeed!
The Summer School was organized by the University of Chemistry and Technology Prague, Institute of Organic Chemistry and Biochemistry of the CAS, Prague, and Weizmann Institute of Science, Rehovot. Results of the Project were presented by Igor Komarov
PELICO Final Workshop took place in a magnificent place, d’Ajol, France. The program of the meeting and the presentation highlighting the main Project achievements are available for download.
Dissemination of the Project results on the VIth conference Toulouse-Kyiv, Toulouse, France
Controlling the Uptake of Diarylethene‐Based Cell‐Penetrating Peptides into Cells Using Light. Tim Schober, Ilona Wehl, Sergii Afonin, Oleg Babii, Anna Iampolska, Ute Schepers, Igor V. Komarov, Anne S. Ulrich ChemPhotoChem, 2019, 3 (6), pp 384-391 DOI: 10.1002/cptc.201900019
Our Project was selected a success story by the EU Directorate: https://ec.europa.eu/research/infocentre/article_en.cfm?id=/research/headlines/news/article_19_03_04_en.html?infocentre&item=Countries&artid=49936&caller=SuccessStories
Ukrainian Days in Baden-Württemberg, ADVANCING SCIENCE AND EDUCATION HROUGH INTERNATIONAL COOPERATION took part in Tübingen, Germany, at the Institute of Physiology II, Department of Neurophysiology
A major milestone of the Project was achieved: optimised lead compounds, gramicidin S-based peptidomimetics, were obtained. The results of the lead optimisation is published in the Journal of Medicinal Chemistry.